Relationship between Thalamic Size and Volume by MRI and Disability in Patients with Multiple Sclerosis


Azad University*



Background: Multiple sclerosis is one of the most common neurological disorders in young adults, which myelin is damaged by pathogens throughout life as high prevalance of the disease and the fact that it is the third cause of neurologic disabilities in Adults and thalamus involvement in this disease, which can cause cognitive impairment and motor disabilities and lower quality of lif.
Purpose: The purpose of this study is evaluating the type of thalamus involvement, changes in volume and size, the relationship between this disease and thalamus involvement, diagnosis in the early stage of the disease, and the prognosis of symptoms and the severity of the sensory and neurological involvement
Methods: In this descriptive cross-sectional study, 40patients with Multiple sclerosis were assigned consequently considering the inclusion criteria after assigning informed consent. Then, EDSS questionnaire was
completed for them. Thalamus size and volume were assesed by MRI. Then, the results were analyzed by SPSS software version 24.
Results: In this study, 40 subjects participated in 23 women (57.5%) and 17 men (42.5%) with a
mean age of 36.3 ± 9.3. Also, 15 (37.5%) were single and Twenty-five (62.5%) were married. Bachelor’s degree and higher (32.5%) and housewives (30%), 8 (20%) were the most frequent
The duration of the disease was 1.4 ± 3.5 years. In the present study, the results showed significant reverse correlation between thalamus volume and disability (P> 0.05) and thalamus size and disability (P> 0.05) and direct linear relationship Between thalamus size and thalamus volume (P> 0.05).
Conclusion: Generally, it can be concluded that in patients with multiple sclerosis, decreasing the size and volume of thalamus increases the incidence of patients’ disability.