Iranian Society of Radiology
To evaluate whether magnetic resonance imaging (MRI) is as effective as Computed Tomography (CT) for determining functional pulmonary changes in patients with cystic fibrosis (CF) during follow-up exams.
Twenty-three patients (12 Males) aging between 1-20 years, CF disease of whom were confirmed by sweat test, were investigated. Patients were evaluated using lung CT scan, and One-week later underwent chest MRI, without contrast injection for either of modalities. Eventually, CT and MRI scores were compared based on individual features incorporated into bhalla scoring system, as well as based on the total calculated score.
There was a strong correlation between Bhalla chest CT and MRI scores (R = 0.97, P<0.0001), with a mean and median difference of 0.61 and 1 points, respectively. The chest CT and MRI showed a high level of agreement to detect all studied variables, including the severity and extent of bronchiectasis (ICC: 98.8% And 97.6%; R = 0.988 And 0.977, Respectively), peribronchial thickening (ICC: 81.4%; R = 0.815), sacculations, generalities of the bronchial division involved, and number of bubbles (ICC: 100%; R = 1), emphysema (ICC: 67.3%; R = 1) and collapse/ consolidation (ICC: 89.1%; R = 0.890).
These results showed that none of the relevant findings were missed by MRI, and more interestingly, and MRI can adequately address morphological changes in follow-up imaging of CF patients.