Second look targeted ultrasound or so-called Diagnostic ultrasound nowadays is commonly performed for an abnormality detected on mammography, such as a mass or an asymmetric and also in the evaluation of lesions detected on MRI, such as mass or non-mass enhancement. Ultrasound is useful in the assessment of palpable masses in dense mammography. Palpable masses with benign sonography characteristics can be managed with short-interval follow-up, rather than biopsy. Also US guided biopsy is preferred way of biopsy even the lesion is first detected on mammography. It is cost effective and easier to perform.